Alexandro Roggio

My research focuses on identifying bioactive natural compounds from medicinal plants and uncovering how they regulate inflammatory and angiogenic processes.

By combining bioactivity-guided isolation with functional cell-based assays, I connect defined molecular entities to specific biological effects. A central objective is the mechanistic characterization of how selected compounds modulate immune cell activation, leukocyte-endothelial adhesion, and integrin-dependent pathways. Using bioinformatics of transcriptomic data alongside proteomic and proteome-wide target fishing approaches and signaling analyses, I define regulatory networks and identify molecular targets.

A particular emphasis of my work is immunometabolism. I investigate how metabolic programs shift between pro- and anti-inflammatory states and how natural products interfere with these adaptations. By integrating signaling and metabolic profiling, I seek to reveal how cellular metabolism shapes inflammatory function.

Beyond their pharmacological potential, selected natural compounds serve as tool molecules to dissect key signaling, adhesion, and metabolic pathways in immune cells. Ultimately, this work aims to uncover regulatory nodes that may offer new strategies for therapeutic intervention in inflammatory diseases.